(jocular) to become unduly agitated or angry—twisted clothing as a metaphor for mental confusion—UK, 1971, in the comic strip Andy Capp
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TO GET YOUR KNICKERS IN A TWIST definition in American English
TO GET YOUR KNICKERS IN A TWIST definition in American English
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Don't Get Your Knickers In A Twist
Don't Get Your Knickers in a Twist - English Idioms & Slang Dictionary
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What is the etymology of the 'get one's knickers in a twist' idiom